WG3: Non-conventional yeasts capabilities and molecular biology (systems/synthetic biology)

Rodrigo Ledesma-Amaro

Rodrigo Ledesma-Amaro


Imperial College London, United Kingdom.


Petri-Jaan Lahtvee

Petri-Jaan Lahtvee


University of Tartu, Estonia



Non-conventional yeasts are capable of metabolizing complex carbon sources and to cope with a wide range of process conditions, using in many cases alternative metabolic routes. Yet, the mechanisms responsible for such traits are mainly unknown or under study. The use of specific techniques such as -omics techniques (e.g. genomics, proteomics, transcriptomics and metabolomics) and the development of particular molecular/genetic tools must be therefore promoted towards studying non-conventional yeast at the molecular, genetic, metabolic and physiology levels to fully understand how these microorganisms deal with these processes.

Improving the knowledge on how non-conventional yeasts strains metabolize unusual substrates (carboxylic acids and biomass-derived sugars) or accumulate unusual products (food additives, enzymes, lipids), are fundamental issues to boost the transition to a more sustainable industry based on renewable raw materials. YEAST4BIO integrates basic research (genetics, systems biology, synthetic biology, etc.) and applied biotechnology groups as well as industrial partners to resolve technological questions and boost the commercialization of bioproducts obtained by non-conventional yeasts.


WG3 aims at exploring the possibilities for applying molecular biology and genomics tools for improvement and development of new non-conventional yeasts strains. Specific metabolic pathways steering to the formation of industrially relevant bioproducts will be investigated by using 1) novel molecular and systems/synthetic biology techniques typically applied to S. cerevisiae and/or 2) specific software for in-silico simulation and -omics data analysis. Also, metabolic engineering studies and system/synthetic biology approaches will be assessed to increase their robustness and production yields.

Specific Tasks of WG3 are:

  • To investigate the current situation and research studies on the potential of non-conventional yeasts for the production of bioproducts from low-cost renewable resources and respective molecular tools available.

  • To improve non-conventional yeast strains in terms of different carbon source utilization, robustness and yields by means of genetic, systems/synthetic biology and biotechnological tools.


CountryParticipantRoleE-mailInstitution of affiliation
AustriaAnton GliederMC memberanton.glieder@bisy.atGraz University of Technology, Institute of Molecular Biotechnology
AustriaDiethard MattanovichMC memberdiethard.mattanovich@boku.ac.atUniversity of Natural Resources and Life Sciences, Veinna
AustriaHarald PichlerMC substituteharald.pichler@tugraz.atGraz University of Technology, Institute of Molecular Biotechnology
BelgiumPatrick FickersMC memberpfickers@uliege.beUniversité de Liege - Gembloux Agro-BioTech
BelgiumSofie de MaeseneireMC substitutesofie.demaeseneire@ugent.beGhent University
Bosnia and HerzegovinaBorut BosancicMC memberborut.bosancic@agro.unibl.orgUniversity of Banja Luka, Faculty of Agriculture, Department of Biometrics
CroatiaIgor StuparevicMC memberistuparevic@pbf.hrLaboratory for Biochemistry, Faculty of Food Technology and biotechnology, University of Zagreb
CroatiaAnamarija ŠtafaParticipantastafa@pbf.hrUniversity of Zagreb, Faculty of Food Technology and Biotechnology
Czech RepublicHana SychrovaITC- Conference Manager/MC memberhana.sychrova@fgu.cas.czDepartment of Membrane Transport, Institute of Physiology, Czech Academy of Sciences
Czech RepublicJakub MasarykMC substitutejakub.masaryk@fgu.cas.czInstitute of Physiology, Czech Academy of Sciences
DenmarkJose Luis Martinez RuizVice-Chair/ MC memberjlmr@dtu.dkTechnical University of Denmark (DTU)
DenmarkCésar FonsecaMC membercsf@bio.aau.dkAalborg University
EstoniaPetri-Jaan LahtveeWG3 Vice-Leader/MC memberlahtvee@ut.eeUniversity of Tartu
EstoniaTiina AlamäeMC membertiina@alamae.euInstitute of Molecular and Cell Biology, University of Tartu
EstoniaNemailla BonturiMC substitutenemailla.bonturi@ut.eeUniversity of Tartu
EstoniaTriinu VisnapuuMC substitutetriinu.visnapuu@ut.eeUniversity of Tartu
FranceJean-Marc NicaudMC memberjean-marc.nicaud@inra.frINRAE
FranceTristan RossignolMC substitutetristan.rossignol@inra.frINRAE
GreeceGeorge AggelisMC membergeorge.aggelis@upatras.grUniversity of Patras
IcelandHjörleifur EinarssonMC memberhei@unak.isUniversity of Akureyri
IrelandJohn MorriseyMC memberj.morrissey@ucc.ieUniversity College Cork
IsraelYoram Gerchman WG1 Vide-Leader/MC membergerchman.yoram@gmail.comOranim college (and University of Haifa)
IsraelGur PinesParticipantgurp@volcani.agri.gov.il
Agricultural Research Organization, Volcani Center
ItalyGennaro AgrimiMC membergennaro.agrimi@uniba.itUniversity of Bari - Department of Biosciences, Biotechnologies and Biopharmaceutics
ItalyPaola BranduardiMC memberpaola.branduardi@unimib.itUniversity of Milano Bicocca
ItalyAlessandro AngeliniMC substitutealessandro.angelini@unive.itCa’ Foscari University of Venice
ItalyLisa SolieriParticipant*lisa.solieri@unimore.itDept. of Life Sciences, University of Modena and Reggio Emilia
LatviaMara GrubeMC membergrube@lu.lvInstitute of Microbiology and Biotechnology, University of Latvia
LuxembourgMagdalena CalusinskaWG6 Leader/MC membermagdalena.calusinska@list.luLuxembourg Institute of Science and technology
PolandAleksandra Maria MironczukMC memberaleksandra.mironczuk@upwr.edu.plWroclaw Univerisity of Environmental and Life Sciences
PolandAndriy SibirnyMC membersibirny@yahoo.comUniversity of Rzeszow, Department of Biotechnology
PortugalIsabel Sá-CorreiaMC memberisacorreia@tecnico.ulisboa.ptiBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa
SerbiaZorana RončevićMC memberron@uns.ac.rsFaculty of Technology Novi Sad, University of Novi Sad
SerbiaRužicaTomičićMC memberruzica.tomicic@yahoo.comFaculty of Technology, University of Novi Sad
SlovakiaMartin RebrošMC membermartin.rebros@stuba.skSlovak University of Technology
SlovakiaMilan CerticMC substitutemilan.certik@stuba.skInstitute of Biotechnology, Faculty of Chemical and Food Technology
SloveniaNina Gunde-CimermanMC membernina.gunde-cimerman@bf.uni-lj.siUniversity of Ljubljana, Biotechnical Faculty, Dept. Biology
SloveniaCene GostinčarMC substitutecene.gostincar@bf.uni-lj.siUniversity of Ljubljana
SpainElia TomásChairelia.tomas@imdea.orgIMDEA Energy Institute
SpainCarmela BellochMC substitutebelloch@iata.csic.esInstitute of Agrochemistry and Food Technology - CSIC
SpainMaría Isabel González SisoParticipantmigs@udc.esUniversidade da Coruña
SpainPau FerrerParticipant*pau.ferrer@uab.catUniversitat Autònoma de Barcelona
SpainAlberto Jiménez García Participant*alji@usal.esMetabolic Engineering Group, Department of Microbiology and Genetics, University of Salamanca
SpainJosé Luis Revuelta Doval Participant*revuelta@usal.esMetabolic Engineering Group, Department of Microbiology and Genetics, University of Salamanca
SwedenCecilia GeijerWG4 Vice-Leader/MC substitutececilia.geijer@chalmers.seChalmers University of Technology
SwedenLisbeth OlssonWG4 Leader/MC memberlisbeth.olsson@chalmers.seChalmers University of Technology
SwedenVolkmar PassothWG2 Leader/MC membervolkmar.passoth@slu.seSwedish University of Agricultural Sciences, Department of Molecular Sciences
SwedenEduard KerkhovenParticipanteduardk@chalmers.seChalmers University of Technology
SwedenCharilaos XirosParticipantcharilaos.xiros@processum.seRISE Processum AB
TurkeyGözde KonurayMC membergkonuray@gmail.comCukurova University Department of Food Engineering, Saricam
TurkeyPinar Çalık Participantpcalik@metu.edu.trMiddle East Technical University
TurkeyBaris Binay
MC substitutebinay@gtu.edu.trGebze Technical University
TurkeyBurcu Gündüz ErgünParticipantburcugunduz3@gmail.com
Ministry of Agriculture and Forestry, Biotechnology Research Center
TurkeyUrartu Ozgur Safak SekerParticipanturartu@bilkent.edu.tr
Bilkent University
UKRodrigo Ledesma-AmaroWG3 Leader/MC memberr.ledesma-amaro@imperial.ac.ukImperial College London
UKChieh HsuMC memberc.hsu@kent.ac.ukUniversity of Kent
UKHuadong Peng MC substituteh.peng@imperial.ac.uk Imperial College London
UKPaul FraserParticipant*p.fraser@rhul.ac.ukRoyal Holloway, University of London